a neural correlate of the processing of multi-second time intervals in primate prefrontal cortex处理的神经关联的测试时间间隔在灵长类动物前额叶皮层.pdfVIP

A Neural Correlate of the Processing of Multi-Second Time Intervals in Primate Prefrontal Cortex 1. 1,2,3,4 . 2,3 1,5 6 Naosugi Yumoto , Xiaofeng Lu * , Thomas R. Henry , Shigehiro Miyachi , Atsushi Nambu , Tomoki Fukai7, Masahiko Takada1,8 1 Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo, Japan, 2 Department of Neurology, School of Medicine, University of Minnesota, Minneapolis, Minnesota, United States of America, 3 Clinical Neuroscience Center, University of Minnesota Medical Center, Fairview, Minneapolis, Minnesota, United States of America, 4 Department of Neurophysiology, School of Medicine, Juntendo University, Tokyo, Japan, 5 Cognitive Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan, 6 Division of System Neurophysiology, National Institute for Physiological Sciences, Okazaki, Aichi, Japan, 7 Laboratory for Neural Circuit Theory, RIKEN Brain Science Institute, Wako, Saitama, Japan, 8 Systems Neuroscience Section, Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan Abstract Several areas of the brain are known to participate in temporal processing. Neurons in the prefrontal cortex (PFC) are thought to contribute to perception of time intervals. However, it remains unclear whether the PFC itself can generate time intervals independently of external stimuli. Here we describe a group of PFC neurons in area 9 that became active when monkeys recognized a particular elapsed time within the range of 1–7 seconds. Another group of area 9 neurons became active only when subjects reprod