a mammalian conserved element derived from sine displays enhancer properties recapitulating satb2 expression in early-born callosal projection neurons哺乳动物守恒的元素来源于正弦显示增强器属性概括satb2表达early-born胼胝体的投射神经元.pdfVIP
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a mammalian conserved element derived from sine displays enhancer properties recapitulating satb2 expression in early-born callosal projection neurons哺乳动物守恒的元素来源于正弦显示增强器属性概括satb2表达early-born胼胝体的投射神经元
A Mammalian Conserved Element Derived from SINE
Displays Enhancer Properties Recapitulating Satb2
Expression in Early-Born Callosal Projection Neurons
1. 2. 1. 1 1¤a 3
Kensuke Tashiro , Anne Teissier , Naoki Kobayashi , Akiko Nakanishi , Takeshi Sasaki , Kuo Yan ,
3¤c 2 4 5¤b 1
Victor Tarabykin , Lisa Vigier , Kenta Sumiyama , Mika Hirakawa , Hidenori Nishihara , Alessandra
2 1
Pierani *, Norihiro Okada *
1 Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Kanagawa, Japan, 2 Centre National de la Recherche
´ ´ ´
Scientifique–Unite Mixte de Recherche 7592, Institut Jacques Monod, Universite Paris Diderot, Sorbonne Paris Cite, Paris, France, 3 Department of Molecular Biology of
¨
Neuronal Signals, Max-Plank-Institute for Experimental Medicine, Gottingen, Germany, 4 National Institute of Genetics, Mishima, Shizuoka, Japan, 5 Bioinformatics Center,
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, Japan
Abstract
Short interspersed repetitive elements (SINEs) are highly repeated sequences that account for a significant proportion of
many eukaryotic genomes and are usually considered ‘‘junk DNA’’. However, we previously discovered that many AmnSINE1
loci are evolutionarily conserved across mammalian geno
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