a case control association study and cognitive function analysis of neuropilin and tolloid-like 1 gene and schizophrenia in the japanese population的病例控制协会研究和认知功能分析neuropilin tolloid-like 1基因在日本人口和精神分裂症.pdfVIP

A Case Control Association Study and Cognitive Function Analysis of Neuropilin and Tolloid-Like 1 Gene and Schizophrenia in the Japanese Population 1. 1. 1,2 3 1,4 Masahiro Banno , Takayoshi Koide , Branko Aleksic *, Kazuo Yamada , Tsutomu Kikuchi , Kunihiro 1 1 1 1 2 5 Kohmura , Yasunori Adachi , Naoko Kawano , Itaru Kushima , Masashi Ikeda , Toshiya Inada , Takeo 3 2 1 Yoshikawa , Nakao Iwata , Norio Ozaki 1 Department of Psychiatry, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Aichi-ken, Japan, 2 Department of Psychiatry, Fujita Health University School of Medicine, Kutsukake, Toyoake, Aichi-ken, Japan, 3 Laboratory for Molecular Psychiatry, RIKEN Brain Science Institute, Wako-city, Saitama, Japan, 4 Matsuzaki Hospital, Miyakojima-ku, Osaka, Japan, 5 Department of Psychiatry, Seiwa Hospital, Institute of Neuropsychiatry, Shinjuku-ku, Tokyo, Japan Abstract Background: Using a knock-out mouse model, it was shown that NETO1 is a critical component of the NMDAR complex, and that loss of Neto1 leads to impaired hippocampal long term potentiation and hippocampal-dependent learning and memory. Moreover, hemizygosity of NETO1 was shown to be associated with autistic-like behavior in humans. Purpose of the Research: We examined the association between schizophrenia and the neuropilin and tolloid-like 1 gene (NETO1). First, we selected eight single nucleotide polymorphisms (SNPs) within the NETO1 locus, based on the Japanese schizophrenia genome wide association study (JGWAS) results and previously conducted associa