a caprine herpesvirus 1 vaccine adjuvanted with mf59？ protects against vaginal infection and interferes with the establishment of latency in goats山羊的疱疹病毒1疫苗佐剂的mf59 防止阴道感染和干扰建立山羊的延迟.pdfVIP

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a caprine herpesvirus 1 vaccine adjuvanted with mf59？ protects against vaginal infection and interferes with the establishment of latency in goats山羊的疱疹病毒1疫苗佐剂的mf59 防止阴道感染和干扰建立山羊的延迟.pdf

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a caprine herpesvirus 1 vaccine adjuvanted with mf59？ protects against vaginal infection and interferes with the establishment of latency in goats山羊的疱疹病毒1疫苗佐剂的mf59 防止阴道感染和干扰建立山羊的延迟

A Caprine Herpesvirus 1 Vaccine Adjuvanted with MF59TM Protects against Vaginal Infection and Interferes with the Establishment of Latency in Goats 1 1 2 3 3 Mariarosaria Marinaro *, Giovanni Rezza , Giuseppe Del Giudice , Valeriana Colao , Elvira Tarsitano , 3 3 3 3 Michele Camero , Michele Losurdo , Canio Buonavoglia , Maria Tempesta ` 1 Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanita, Rome, Italy, 2 Research Center, Novartis Vaccines and Diagnostic, Siena, Italy, 3 Department of Veterinary Public Health, University of Bari, Bari, Italy Abstract The immunogenicity and the efficacy of a beta-propiolactone-inactivated caprine herpesvirus 1 (CpHV-1) vaccine adjuvanted with MF59TM were tested in goats. Following two subcutaneous immunizations, goats developed high titers of CpHV-1-specific serum and vaginal IgG and high serum virus neutralization (VN) titers. Peripheral blood mononuclear cells (PBMC) stimulated in vitro with inactivated CpHV-1 produced high levels of soluble IFN-gamma and exhibited high frequencies of IFN-gamma producing cells while soluble IL-4 was undetectable. On the other hand, control goats receiving the inactivated CpHV-1 vaccine without adjuvant produced only low serum antibody responses. A vaginal challenge with ¨ virulent CpHV-1 was performed in all vaccinated goats and in naıve goats to assess t