a hepatic protein, fetuin-a, occupies a protective role in lethal systemic inflammation肝蛋白质、fetuin-a在致命的系统性炎症占据了一个保护的作用.pdfVIP

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a hepatic protein, fetuin-a, occupies a protective role in lethal systemic inflammation肝蛋白质、fetuin-a在致命的系统性炎症占据了一个保护的作用.pdf

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a hepatic protein, fetuin-a, occupies a protective role in lethal systemic inflammation肝蛋白质、fetuin-a在致命的系统性炎症占据了一个保护的作用

A Hepatic Protein, Fetuin-A, Occupies a Protective Role in Lethal Systemic Inflammation 1,2. 1,2. 1 1,3 1,3 3 1 Wei Li , Shu Zhu , Jianhua Li , Yan Huang , Rongrong Zhou , Xuegong Fan , Huan Yang , Xing Gong4 4 5 1 1 , N. Tony Eissa , Willi Jahnen-Dechent , Ping Wang , Kevin J. Tracey , Andrew E. Sama1,2, Haichao Wang1,2* 1The Feinstein Institute for Medical Research, Manhasset, New York, United States of America, 2 Department of Emergency Medicine, North Shore University Hospital, Manhasset, New York, United States of America, 3 Department of Infectious Diseases, Xiangya Hospital, Central South University, Changsha, People’s Republic of China, 4 Pulmonary Critical Care and Sleep Medicine Section, Baylor College of Medicine, Houston, Texas, United States of America, 5 Department of Biomedical Engineering, Biointerface Laboratory, RWTH Aachen University Hospital, Aachen, Germany Abstract Background: A liver-derived protein, fetuin-A, was first purified from calf fetal serum in 1944, but its potential role in lethal systemic inflammation was previously unknown. This study aims to delineate the molecular mechanisms underlying the regulation of hepatic fetuin-A expression during lethal systemic inflammation (LSI), and investigated whether alterations of fetuin-A levels affect animal survival, and influence systemic accumulation of a late mediator, HMGB1. Methods and Findings: LSI was induced by endotoxemia or cecal ligation and puncture (CLP) in fetuin-A knock-out or wild- type mice, and animal survival rates were compared. Murine peritoneal macrophages were challenged with e