3b-o-trans-ferulyl-2a,19a-dihydroxy-urs-12-en-28-oic acid3 b-o-trans-ferulyl-2a 19 a-dihydroxy-urs-12-en-28-oic酸.pdfVIP

3b-O-trans-Ferulyl-2a,19a-dihydroxy-urs-12-en-28-oic Acid Molbank 2003, M328 3bOtransFerulyl2a,19adihydroxyurs12en28oic Acid, A ew Pentacyclic Triterpene Ester from Rubus aleaefolius, Which Inhibits Mammalian Cell Cycle at G2/M phase 1,2 1,3,* 1 2 4 QingChun Zhao , ChengBin Cui , Bing Cai , XinSheng Yao , and Hiroyouki Osada 1 Tianjin Institute for Biomedicinal Research (TIBiR), 3F. D2-Building, Xinmao Technology Park, Huayuan Industrial District, Tianjin 300384, China. Tel.(+86)22 Fax (+86)22 * cuicb@ 2 Shenyang Pharmaceutical University, Shenyang 110016 3 Marine Drug and Food Institute, Ocean University of China, Qingdao 266003 4 The Institute of Physical and Chemical Research (RIKEN), Saitama 351-0198, Japan Received: 22 February 2002 / Accepted: 25 February 2002 / Published: 3 May 2003 Keywords: 3b-O-trans-ferulyl-2a,19a-dihydroxy-urs-12-en- 28-oic acid, pentacyclic triterpene, triterpene, Rubus aleaefolius, cell cycle inhibitor Continuing our studies on bioactive constituents of Rubus aleaefolius Poir. (family Rosacae) [1,2], we report here a new pentacyclic triterpene ester, 3b-Otrans-ferulyl-2a,19a-dihydroxy-urs-12-en- 28-oic acid (1) from Rubus aleaefolius Poir., which inhibits mammalian cell cycle at G2/M phase. The roots (3 kg) of R. aleaefolius were extracted with 60% aqueous alcohol to give an alcoholic extract (435 g) possessing potential inhibitory activity on cell cycle of tsFT210 cells [1]. The alcoholic extract was thus suspended in water and then extracte