4,4’-[(2-chlorophenyl)methylene]bis[1-phenyl-3-(trifluoromethyl)-1h-pyrazol-5-ol]4,4u2019-[(2-chlorophenyl)亚甲基]bis[1-phenyl-3 -(trifluoromethyl)1 h-pyrazol-5-ol].pdfVIP

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4,4’-[(2-chlorophenyl)methylene]bis[1-phenyl-3-(trifluoromethyl)-1h-pyrazol-5-ol]4,4u2019-[(2-chlorophenyl)亚甲基]bis[1-phenyl-3 -(trifluoromethyl)1 h-pyrazol-5-ol].pdf

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4,4’-[(2-chlorophenyl)methylene]bis[1-phenyl-3-(trifluoromethyl)-1h-pyrazol-5-ol]4,4u2019-[(2-chlorophenyl)亚甲基]bis[1-phenyl-3 -(trifluoromethyl)1 h-pyrazol-5-ol]

Molbank 2009, M605 OPEN ACCESS molbank ISSN 1422-8599 /journal/molbank Short Note 4,4’-[(2-Chlorophenyl)methylene]bis[1-phenyl-3- (trifluoromethyl)-1H-pyrazol-5-ol] Changbin Guo 1,2 and Wolfgang Holzer 1,* 1 Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, A-1090 Vienna, Austria 2 Department of Chemistry, Capital Normal University, Xisanhuanbei Road 105, Beijing, 100048, China * Author to whom correspondence should be addressed; E-mail: wolfgang.holzer@univie.ac.at Received: 3 July 2009 / Accepted: 14 July 2009 / Published: 16 July 2009 Abstract: The reaction of 1-phenyl-3-trifluoromethyl-2-pyrazolin-5-one and 2-chloro- benzaldehyde leads to the title compound, which results from addition of a second pyrazolone unit to the primarily formed 1:1 condensation product. Detailed spectroscopic 1 13 19 data ( H NMR, C NMR, F NMR, IR, MS) are presented. Keywords: 3-trifluoromethyl-2-pyrazolin-5-one; condensation; NMR spectroscopy In the course of a synthetic program dedicated to the functionalization of 1-phenyl-3- trifluoromethyl-2-pyrazolin-5-one (1) [1] we were interested in compound 2, which was considered as precursor in the synthesis of the chromeno[2,3-c]pyrazol-4(1H)-one 3 (Scheme 1). The synthesis of compounds similar to 2 has been described by Sobahi [2] and by Zohdi [3]: heating equimolar amounts of 1 and differently substituted benzaldehydes to 160 °C without a solvent re