不同剂量阿托伐他汀对ACS患者血浆妊娠相关蛋白A及hs-CRP影响.docVIP

不同剂量阿托伐他汀对ACS患者血浆妊娠相关蛋白A及hs-CRP影响摘要：目的 探讨不同剂量阿托伐他汀对ACS病人妊娠相关蛋白A（PAPP-A）和高敏C反应蛋白（hs-CRP）水平的影响。方法 104例有临床症状或冠脉造影结果证实冠心病病人，根据阿托伐他汀剂量的不同分为10 mg组、20 mg组、40 mg组，测定基线和第1周及第4周PAPP-A和hs-CRP水平。结果 73例急性冠脉综合征病人血浆PAPP-A、hs-CRP水平高于稳定心绞痛病人（P ［2］ Stulc T,Malbohan I,Malik J,et al.Increased levels of pregnancy-associated plama protein-A inpatients with hypercholesterolemia:The effect of atorstatin treatment［J］.Am Heart J,2003,146:1060-1063. ［3］ Aso Y,Okumura K,Wakabayashi S,et al.Elevated pregnancy-associated plasma protein-A insera from type 2 diadetic patients with hypercholesterolemia:Associations with carotid atherosclerosis and toe-brachial index［J］.J Clin Endocrinol Metab,2004,89:5713-5717. ［4］ Bayes-Genis A,Conover C,Overgaard MT,et al.Pregnancy-associated plasma protein A as a marker of acute coronary syndromes［J］.N Engl J Med,2001,345:1022-1029. ［5］ Heeschen C,Dimmeler S,Hamm CW,et al.Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes［J］.J Am Coll Cardiol,2005,45:229-237. ［6］ Lund J,Qin QP,Ilva T,et al.Circulating pregnancy -associated plasma protein-A predicts outcome in patients with acute coronary syndrome but no troponin I elevation［J］.Circulation,2003,108:1924-1926. ［7］ Schwartz GG,Olsson AG,Ezekowitz MD,et al.Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes:The MIRACL study:A randomized controlled trial［J］.JAMA,2001,285:1711-1718. ［8］ Kinlay S,Schwartz GG,Olsson AG,et al.High-dose atorvastatin enhances the decline in inflammatory markers in patients with acute coronary syndromes:The MIRACL study［J］.Circulation,2003,108:1560-1566. ［9］ Dominguez A,Abreu-Gonzalez P,Garcia-Gonzalez M,et al.Circulating pregnancy -associated plasma protein-A is not an early marker of acute myocardial infarction［J］.Clin Chem,1997,43:2323-2332. ［10］ Qin QP,Kokkala S,Lund J,et al.Molecular distinction of circulating pregnancy -associated plasma protein-A in myocardial infarction and preg