米索前列醇舌下含服用于早孕药物流产（Sublingual misoprostol is used for miscarriage in the early pregnancy）.docVIP

米索前列醇舌下含服用于早孕药物流产（Sublingual misoprostol is used for miscarriage in the early pregnancy） Sublingual misoprostol is used for miscarriage in the early pregnancy Update Date: 12-04 [Keywords] misoprostol, drug abortion Health News: Zhang Yujuan (review) Li Yi (300211 Revision) obstetrics and Gynecology Department of Second Hospital Affiliated to Tianjin Medical University Misoprostol (Misoprostol, Miso) was a synthetic prostaglandin E 1 in 1980s Derivatives, formerly used in the treatment of peptic ulcers, have been proposed for the first time since 1987 by Rabe et al. Miso have termination of early pregnancy Has been widely used in early pregnancy drug abortion [1]. Miso is mostly administered by vaginal or oral administration, However, vaginal delivery is inconvenient and easy to increase the chances of infection, individual cases of incomplete dissolution of drugs or vaginal bleeding may be too much Although the effect of drug absorption is good, the curative effect is mild, and some patients suffer from vomiting The effect of drug loss, influence, fasting time is too easy to cause hypoglycemia reaction. Recently, some foreign scholars began To explore the method of sublingual administration, and to demonstrate its feasibility and superiority, which has opened up more for early pregnancy drug abortion Add simple and effective new ways. The pharmacological basis and related research of sublingual administration of 1 Miso sublingual gland 1.1 the absorption mechanism of sublingual drugs was related to the rate of absorption of sublingual drugs in various routes of administration And bioavailability are second only to intravenous injection and inhalation. The mucous membrane of the tongue is penetrating, and the blood flowing through the mucous membrane passes through the tongue The veins, facial veins, posterior palatine veins and internal jugular veins enter the circulatory system directly, thus avoiding the first pass effect of the liver, The digestion of gastrointe