类风湿关节炎实验室检查的进展及其临床应用（Progress and clinical application of laboratory examination for rheumatoid arthritis）.docVIP

类风湿关节炎实验室检查的进展及其临床应用（Progress and clinical application of laboratory examination for rheumatoid arthritis） Progress and clinical application of laboratory examination for rheumatoid arthritis 2007-12-07 #e# Rheumatoid arthritis (rheumatoid, arthritis, RA) is the most common form of rheumatic disease, the prevalence of the world is about 1%, the annual incidence of adults is about 3/10000 [1]. It is estimated that there are about 4 million [2] patients in the mainland. It can be seen that the disease has a wide range of hazards. Because the clinical diagnosis of RA lacks specific laboratory indicators, it can only rely on clinical symptoms and X ray manifestations, resulting in RA missed diagnosis and misdiagnosis. Therefore, many scholars have explored the diagnostic methods with high specificity and sensitivity for RA diagnosis, and have made great progress. New laboratory methods and their clinical significance at home and abroad in recent years are described as follows. 1 detection of rheumatoid factor (RF) In 1912, it was found that the serum of patients with RA contained RF, not only for the diagnosis of RA, but also for the study of the pathogenesis of RA. However, RF is not a satisfactory diagnostic marker, because the detection rate of RF in RA patients is not high and the specificity is low. In addition, RF is often negative in early RA. In recent years, various new methods for detecting RF have appeared in succession, and the detection rate of RA has been improved. In 1992, Jiang Ming et al reported [3]: serum RF was detected by dot immuno binding assay (DIBA), the positive rate was 59%, and the positive rate of IgM, IgG and IgA RF was 73% in RA patients. Only a few SLE, systemic sclerosis, polymyositis and dermatomyositis patients with IgM-RF, and the titer is low. In 1993 Liu Shu [4] separated by immune complex - ELISA test method for immune complex dissociation enzyme to detect hidden rheumatoid factor (HRF), found in the activities of RA, IgM type of h