natural host genetic resistance to lentiviral cns disease a neuroprotective mhc class i allele in siv-infected macaques自然宿主基因抵抗慢病毒中枢神经系统疾病的神经保护mhc类我在siv-infected猕猴等位基因.pdfVIP

Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV- Infected Macaques 1,2,3 1 4 5 Joseph L. Mankowski *, Suzanne E. Queen , Caroline S. Fernandez , Patrick M. Tarwater , Jami M. 1 1 4 Karper , Robert J. Adams , Stephen J. Kent 1 Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 2 Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 3 Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, 4 Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia, 5 Department of Biomedical Sciences, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, Texas, United States of America Abstract Human immunodeficiency virus (HIV) infection frequently causes neurologic disease even with anti-retroviral treatment. Although associations between MHC class I alleles and acquired immunodeficiency syndrome (AIDS) have been reported, the role MHC class I alleles play in restricting development of HIV-induced organ-specific diseases, including neurologic disease, has not been characterized. This study examined the relationship between expression of the MHC class I allele Mane-A*10 and development of lentiviral-induced central nervous system (CNS) disease using a well-characterized simian immunodeficiency (SIV)/pigtailed macaque model. The risk of developing CNS disease (SIV encephalitis) was 2.5 times higher for