mos11 a new component in the mrna export pathwaymos11 mrna的新组件出口通道.pdfVIP

MOS11: A New Component in the mRNA Export Pathway 1,2. 3. 1 4 1 1 Hugo Germain , Na Qu , Yu Ti Cheng , EunKyoung Lee , Yan Huang , Oliver Xiaoou Dong , Patrick 1 3 3 3 4 3 1,4 Gannon , Shuai Huang , Pingtao Ding , Yingzhong Li , Fred Sack , Yuelin Zhang *, Xin Li * 1 Michael Smith Laboratories, University of British Columbia, Vancouver, Canada, 2 Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Stn. Sainte-Foy, Canada, 3 National Institute of Biological Sciences, Beijing, China, 4 Department of Botany, University of British Columbia, Vancouver, Canada Abstract Nucleocytoplasmic trafficking is emerging as an important aspect of plant immunity. The three related pathways affecting plant immunity include Nuclear Localization Signal (NLS)–mediated nuclear protein import, Nuclear Export Signal (NES)– dependent nuclear protein export, and mRNA export relying on MOS3, a nucleoporin belonging to the Nup107–160 complex. Here we report the characterization, identification, and detailed analysis of Arabidopsis modifier of snc1, 11 (mos11). Mutations in MOS11 can partially suppress the dwarfism and enhanced disease resistance phenotypes of snc1, which carries a gain-of-function mutation in a TIR-NB-LRR type Resistance gene. MOS11 encodes a conserved eukaryotic protein with homology to the human RNA binding protein CIP29. Further functional analysis shows that MOS11 localizes to the nucleus and that the mos11 mutants accumulate more poly(A) mRNAs in the nucleus, likely resulting from reduced mRNA export ac