有哪些信誉好的足球投注网站nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice鼻交付绕过adenovirus-based疫苗免疫力的疫苗载体,提高小鼠的免疫反应.pdfVIP
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nasal delivery of an adenovirus-based vaccine bypasses pre-existing immunity to the vaccine carrier and improves the immune response in mice鼻交付绕过adenovirus-based疫苗免疫力的疫苗载体,提高小鼠的免疫反应
Nasal Delivery of an Adenovirus-Based Vaccine Bypasses Pre-Existing Immunity to the Vaccine Carrier and Improves the Immune Response in Mice 1,2 3,4 3 3 5 3,4,6 Maria A. Croyle , Ami Patel , Kaylie N. Tran , Michael Gray , Yi Zhang , James E. Strong , Heinz Feldmann3,4, Gary P. Kobinger3,4* 1 Division of Pharmaceutics, College of Pharmacy, The University of Texas at Austin, Austin, Texas, United States of America, 2 Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, United States of America, 3 Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada, 4 Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada, 5 Department of Internal Medicine, Division of Immunology, University of Michigan, Ann Arbor, Michigan, United States of America, 6 Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada Abstract Pre-existing immunity to human adenovirus serotype 5 (Ad5) is common in the general population. Bypassing pre-existing immunity could maximize Ad5 vaccine efficacy. Vaccination by the intramuscular (I.M.), nasal (I.N.) or oral (P.O.) route with ¨ Ad5 expressing Ebola Zaire glycoprotein (Ad5-ZGP) fully protected naıve mice against lethal challenge with Ebola. In the presence of pre-existing immunity, only mice vaccinated I.N. survived. The frequency of IFN-c+ CD8+ T cells was reduced by 80% and by 15% in animals vaccinated by the I.M. and P.O. routes respectively. Neutralizing antibodies could not be detected in serum from either treatment
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