morphology, classification, and distribution of the projection neurons in the dorsal lateral geniculate nucleus of the rat投射神经元的形态、分类和分布的背外侧膝状体核老鼠.pdfVIP

Morphology, Classification, and Distribution of the Projection Neurons in the Dorsal Lateral Geniculate Nucleus of the Rat 1 2 3 Changying Ling , Michael L. Hendrickson , Ronald E. Kalil * 1 Department of Surgery, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 W.M. Keck Laboratory for Biological Imaging, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 3 Department of Ophthalmology and Visual Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, United States of America Abstract The morphology of confirmed projection neurons in the dorsal lateral geniculate nucleus (dLGN) of the rat was examined by filling these cells retrogradely with biotinylated dextran amine (BDA) injected into the visual cortex. BDA-labeled projection neurons varied widely in the shape and size of their cell somas, with mean cross-sectional areas ranging from 60–340 mm2. Labeled projection neurons supported 7–55 dendrites that spanned up to 300 mm in length and formed dendritic arbors with cross-sectional areas of up to 7.0 6104 2 mm . Primary dendrites emerged from cell somas in three broad patterns. In some dLGN projection neurons, primary dendrites arise from the cell soma at two poles spaced approximately 180u apart. In other projection neurons, dendrites emerge principally from one side of the cell soma, while in a third group of projection neurons primary dendrites emerge from the entire perimeter of the cell soma. Based on these three distinct patterns in the distribution of primary dendrites from cell somas, we have grouped dLGN projection neurons into three classes: bipol