有哪些信誉好的足球投注网站n-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats防治和别嘌呤醇协同增强心脏脂联素含量,降低糖尿病大鼠心肌再灌注损伤.pdfVIP
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n-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats防治和别嘌呤醇协同增强心脏脂联素含量,降低糖尿病大鼠心肌再灌注损伤
N-Acetylcysteine and Allopurinol Synergistically Enhance Cardiac Adiponectin Content and Reduce Myocardial Reperfusion Injury in Diabetic Rats 1 1 1 1 1,2,3 2,3,4 Tingting Wang , Shigang Qiao , Shaoqing Lei , Yanan Liu , Kwok F. J. Ng , Aimin Xu , Karen S. L. Lam2,4, Michael G. Irwin1,2*, Zhengyuan Xia1,2* 1 Department of Anaesthesiology, The University of Hong Kong, Hong Kong SAR, China, 2 Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong SAR, China, 3 Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR, China, 4 Department of Medicine, The University of Hong Kong, Hong Kong SAR, China Abstract Background: Hyperglycemia-induced oxidative stress plays a central role in the development of diabetic myocardial complications. Adiponectin (APN), an adipokine with anti-diabetic and anti-ischemic effects, is decreased in diabetes. It is unknown whether or not antioxidant treatment with N-acetylcysteine (NAC) and/or allopurinol (ALP) can attenuate APN deficiency and myocardial ischemia reperfusion (MI/R) injury in the early stage of diabetes. Methodology/Principal Findings: Control or streptozotocin (STZ)-induced diabetic rats were either untreated (C, D) or treated with NAC (1.5 g/kg/day) or ALP (100 mg/kg/day) or their combination for four weeks starting one week after STZ injection. Plasma and cardiac biochemical parameters were measured after the completion of treatment, and the rats were subjected to MI/R by occluding the left anterior descending artery for 30 min followed by 2 h reperfusion. Plasma and cardiac APN levels were decreased in diabetic rats accompanied by decreased
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