mushroom ganoderma lucidum prevents colitis-associated carcinogenesis in mice蘑菇灵芝防止colitis-associated老鼠体内的致癌作用.pdfVIP

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mushroom ganoderma lucidum prevents colitis-associated carcinogenesis in mice蘑菇灵芝防止colitis-associated老鼠体内的致癌作用.pdf

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mushroom ganoderma lucidum prevents colitis-associated carcinogenesis in mice蘑菇灵芝防止colitis-associated老鼠体内的致癌作用

Mushroom Ganoderma lucidum Prevents Colitis- Associated Carcinogenesis in Mice 1,2,4 1 1 1 5 1 Daniel Sliva *, Jagadish Loganathan , Jiahua Jiang , Andrej Jedinak , John G. Lamb , Colin Terry , 3 6 3 1 Lee Ann Baldridge , Jiri Adamec , George E. Sandusky , Shailesh Dudhgaonkar 1 Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America, 2 Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 3 Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 4 Indiana University Cancer Center, Indiana University School of Medicine, Indianapolis, Indiana, United States of America, 5 Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah, United States of America, 6 Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, United States of America Abstract Background: Epidemiological studies suggest that mushroom intake is inversely correlated with gastric, gastrointestinal and breast cancers. We have recently demonstrated anticancer and anti-inflammatory activity of triterpene extract isolated from mushroom Ganoderma lucidum (GLT). The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice. Methods/Principal Findings: Colon carcinogenesis was induced by the food-borne carcinogen (2-Amino-1-methyl-6- phenylimidazol[4,5-b]pyridine [PhIP]) and inflammation (dextran sodium sulfate [DSS]) in mice. Mice were treated with 0, 100, 300