mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment粘膜抗菌肽基因表达的炎症性肠病之前和之后的第一次英夫利昔单抗治疗.pdfVIP

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mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment粘膜抗菌肽基因表达的炎症性肠病之前和之后的第一次英夫利昔单抗治疗.pdf

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mucosal gene expression of antimicrobial peptides in inflammatory bowel disease before and after first infliximab treatment粘膜抗菌肽基因表达的炎症性肠病之前和之后的第一次英夫利昔单抗治疗

Mucosal Gene Expression of Antimicrobial Peptides in Inflammatory Bowel Disease Before and After First Infliximab Treatment 1,2. 3. 2 2 2 Ingrid Arijs , Gert De Hertogh , Katleen Lemaire , Roel Quintens , Leentje Van Lommel , Kristel Van 4 4 1 1 ´ 1 3 Steen , Peter Leemans , Isabelle Cleynen , Gert Van Assche , Severine Vermeire , Karel Geboes , Frans Schuit2*, Paul Rutgeerts1,5* 1 Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium, 2 Gene Expression Unit, Department of Molecular Cell Biology, Katholieke Universiteit Leuven, Leuven, Belgium, 3 Department of Morphology and Molecular Pathology, University Hospital Gasthuisberg, Leuven, Belgium, 4 Department of Electrical Engineering and Computer Science (Montefiore Institute), University of Liege, Liege, Belgium, 5 Leuven Food Science and Nutrition Research Centre (LFoRCe), University Hospital Gasthuisberg, Leuven, Belgium Abstract Background: Antimicrobial peptides (AMPs) protect the host intestinal mucosa against microorganisms. Abnormal expression of defensins was shown in inflammatory bowel disease (IBD), but it is not clear whether this is a primary defect. We investigated the impact of anti-inflammatory therapy with infliximab on the mucosal gene expression of AMPs in IBD. Methodology/Principal Findings: Mucosal gene expression of 81 AMPs was assessed in 61 IBD patients before and 4–6 weeks after their first infliximab infusion and in 12 control patients, using Affymetrix arrays. Quantitative real-time reverse- transcription PCR and immunohistochemistry were u