mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease significant association with muc5ac粘蛋白可变数目串联重复序列多态性和严重程度的囊性纤维化肺病和muc5ac的显著联系.pdfVIP

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mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease significant association with muc5ac粘蛋白可变数目串联重复序列多态性和严重程度的囊性纤维化肺病和muc5ac的显著联系.pdf

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mucin variable number tandem repeat polymorphisms and severity of cystic fibrosis lung disease significant association with muc5ac粘蛋白可变数目串联重复序列多态性和严重程度的囊性纤维化肺病和muc5ac的显著联系

Mucin Variable Number Tandem Repeat Polymorphisms and Severity of Cystic Fibrosis Lung Disease: Significant Association with MUC5AC 1 1 1 1 1 XueLiang Guo , Rhonda G. Pace , Jaclyn R. Stonebraker , Clayton W. Commander , Anthony T. Dang , 2 3 4 5 4 1. Mitchell L. Drumm , Ann Harris , Fei Zou , Dallas M. Swallow , Fred A. Wright , Wanda K. O’Neal , 1,6 . Michael R. Knowles * 1 Cystic Fibrosis/Pulmonary Research and Treatment Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 2 Departments of Pediatrics and Genetics, Case Western Reserve University, Cleveland, Ohio, United States of America, 3 Human Molecular Genetics Program, Children’s Memorial Research Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America, 4 Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, 5 Research Department of Genetics, Evolution and Environment, University College London, London, United Kingdom, 6 Gene Modifier Study Group, Chapel Hill, North Carolina, United States of America Abstract Variability in cystic fibrosis (CF) lung disease is partially due to non-CFTR genetic modifiers. Mucin genes are very polymorphic, and mucins play a key role in the pathogenesis of CF lung disease; therefore, mucin genes are strong candidates as genetic modifiers. DNA from CF patients recruited for extremes of lung phenotype was analyzed by So