motifs, control, and stability图案、控制和稳定.pdfVIP

Open access, freely available online Primer Motifs, Control, and Stability John Doyle*, Marie Csete any of the detailed mechanisms by which “stability” as preservation of a specifi c behavior over time bacteria express genes in response to various under some set of perturbations. The defi nitions of stability environmental signals are well-known. The molecular vary somewhat depending on the types of system, behavior, M players underlying these responses are part of a bacterial and perturbation specifi ed [2]. For the BTN example, Prill et transcriptional regulatory network (BTN). To explore the al. [1] study stability of gene expression levels, as modeled by properties and evolution of such networks and to extract a set of linear differential equations. Given interactions from general principles, biologists have looked for common themes a BTN motif, “structural stability” is robustness of stability to or motifs, and their interconnections, such as reciprocal links arbitrary signs and magnitudes of interactions. This is such or feedback loops. A BTN motif can be thought of as a directed a stringent notion of stability that it would be satisfi ed by graph with regulatory interactions connecting transcription few systems, yet Prill et al. [1] show that all BTN motifs are factors to their operon targets (the set of related bacterial stable for all signs and magnitudes of interactions. For several genes that are transcribed together). For example, Figure 1A other biological networks, they show a lev