有哪些信誉好的足球投注网站monocyte chemotactic protein-1 (mcp-1) and growth factors called into question as markers of prolonged psychosocial stress单核细胞趋化蛋白1(mcp-1)和生长因子质疑长期心理社会应激的标记.pdfVIP
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monocyte chemotactic protein-1 (mcp-1) and growth factors called into question as markers of prolonged psychosocial stress单核细胞趋化蛋白1(mcp-1)和生长因子质疑长期心理社会应激的标记
Monocyte Chemotactic Protein-1 (MCP-1) and Growth Factors Called into Question as Markers of Prolonged Psychosocial Stress ¨ 1 ¨ 1 1 2 Ingibjorg H. Jonsdottir *, Daniel A. Hagg , Kristina Glise , Rolf Ekman 1The Institute of Stress Medicine, Gothenburg, Sweden, 2 Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Abstract Background: Psychosocial stress is becoming a major contributor to increased mental ill-health and sick leave in many countries. Valid markers of chronic stress would be valuable for diagnostic and prognostic purposes. A recent study suggested monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as markers of chronic stress. We aimed to confirm these potential biomarkers of prolonged psychosocial stress in female patients. Methodology/Principal Findings: Circulating levels of MCP-1, EGF and VEGF, along with several other cytokines, were measured in plasma from 42 female patients suffering from exhaustion due to prolonged psychosocial stress and 42 control subjects, using a protein biochip immunoassay. There were no significant differences between patients and controls in any of the cytokines or growth factors analyzed. Furthermore, when using a different protein bioassay and reanalyzing MCP-1 and VEGF in the same samples, markedly different levels were obtained. To further explore if inflammation is present in patients with exhaustion, the classical inflammatory marker C-reactive protein (CRP) was measured in another group of patients (n = 89) and controls (n = 88) showing a small but significant increase of CRP levels in the patients. Conclusions/Significance:
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