morphological and glucose metabolism abnormalities in alcoholic korsakoffs syndrome group comparisons and individual analyses形态和葡萄糖代谢异常在酒精健忘综合征组比较和个人分析.pdfVIP

Morphological and Glucose Metabolism Abnormalities in Alcoholic Korsakoff’s Syndrome: Group Comparisons and Individual Analyses 1,2 ´ 1 ¨ ´ 1 ´ 1 ´ ` 1 Anne-Lise Pitel , Anne-Marie Aupee , Gael Chetelat , Florence Mezenge , Helene Beaunieux , Vincent 1,3 1,3 4 1 ´ 1 de la Sayette , Fausto Viader , Jean-Claude Baron , Francis Eustache , Beatrice Desgranges * ´ ´ ˆ 1 Inserm – EPHE – Universite de Caen/Basse-Normandie, Unite U923, GIP Cyceron, CHU Cote de Nacre, Caen, France, 2 Department of Psychiatry and Behavioral Sciences, ´ Stanford University, Stanford, California, United States of America, 3 CHU Cote de Nacre, Departement de Neurologie, Caen, France, 4 University of Cambridge, Department of Clinical Neurosciences, Neurology Unit, Cambridge, United Kingdom Abstract Background: Gray matter volume studies have been limited to few brain regions of interest, and white matter and glucose metabolism have received limited research attention in Korsakoff’s syndrome (KS). Because of the lack of brain biomarkers, KS was found to be underdiagnosed in postmortem studies. Methodology/Principal Findings: Nine consecutively selected patients with KS and 22 matched controls underwent both structural magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography examinations. Using a whole-brain analysis, the between-group comparisons of gray matter and white matt