human papillomavirus persistence in young unscreened women, a prospective cohort study人类乳头状瘤病毒的持久性在未屏蔽的年轻女性,前瞻性群组研究.pdfVIP

Human Papillomavirus Persistence in Young Unscreened Women, a Prospective Cohort Study 1 2 3 4 Channa E. Schmeink *, Willem J. G. Melchers , Albertus G. Siebers , Wim G. V. Quint , Leon F. A. G. Massuger1, Ruud L. M. Bekkers1 1 Department of Obstetrics and Gynaecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 2 Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 3 Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands, 4 DDL Diagnostic Laboratory, Voorburg, The Netherlands Abstract Objective: To evaluate hr-HPV persistence and associated risk factors in a prospective cohort of young unscreened women. Additionally, the relation between hr-HPV status and cytology/histology results is examined. Methods and Principal Findings: Two year follow-up of 235 out of 2065 young women (18–29 years), participating in a large, one year epidemiological study, with questionnaires, self-collected cervico-vaginal samples (Vibabrush), and SPF10LiPA for HPV detection. Only women hr-HPV positive at sample month 12 were invited for a second year of follow-up. After study follow-up, available cytology/histology data were requested from PALGA (the national network and registry of histo- and cytopathology in The Netherlands). These data were compared with available cytology/histology data of the month 12 hr-HPV negative women from the same cohort. 44.1% of the hr-HPV types detected at study month 12, persisted during follow-up. HPV types 45, 31, 16 and 18 were most likely to persist with percentages of 60.0%, 56.8%, 54.4%,and 50.0%, respectively. Compared to newly detected infections