有哪些信誉好的足球投注网站mono-(2-ethylhexyl) phthalate directly alters the expression of leydig cell genes and cyp17 lyase activity in cultured rat fetal testismono -邻苯二甲酸二(2-ethylhexyl)直接改变睾丸间质细胞基因的表达和cyp17裂合酶活动培养大鼠胎儿睾丸.pdfVIP
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mono-(2-ethylhexyl) phthalate directly alters the expression of leydig cell genes and cyp17 lyase activity in cultured rat fetal testismono -邻苯二甲酸二(2-ethylhexyl)直接改变睾丸间质细胞基因的表达和cyp17裂合酶活动培养大鼠胎儿睾丸
Mono-(2-ethylhexyl) Phthalate Directly Alters the Expression of Leydig Cell Genes and CYP17 Lyase Activity in Cultured Rat Fetal Testis ´ 1 2 ´ 1 4 Franc¸ois Chauvigne , Simon Plummer , Laurianne Lesne , Jean-Pierre Cravedi , Nathalie Dejucq- 1 3 ´ 1 Rainsford , Alexis Fostier , Bernard Jegou * ´ ´ ´ 1 Inserm (Institut National de la Sante et de la Recherche Medicale), U625, IRSET (Institut de Recherche sur la Sante, l’Environnement et le Travail), Rennes, France, 2 CXR Biosciences Ltd, Dundee, United Kingdom, 3 INRA (Institut National de la Recherche Agronomique), UR1037 SCRIBE (Station Commune de Recherche en ´ Ichtyophysiologie, Biodiversite et Environnement), Rennes, France, 4 INRA Toxalim, UMR 1331, Toulouse, France Abstract Exposure to phthalates in utero alters fetal rat testis gene expression and testosterone production, but much remains to be done to understand the mechanisms underlying the direct action of phthalate within the fetal testis. We aimed to investigate the direct mechanisms of action of mono-(2-ethylhexyl) phthalate (MEHP) on the rat fetal testis, focusing on Leydig cell steroidogenesis in particular. We used an in vitro system based on the culture for three days, with or without MEHP, of rat fetal testes obtained at 14.5 days post-coitum. Exposure to MEHP led to a dose-dependent decrease in testosterone production. Moreover, the production of 5 alpha-dihydrotestosterone (5a-DHT) ( 268%) and androstenedione (254%) was also inhibited by 10 mM MEHP,
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