molecular pathways involved in prostate carcinogenesis insights from public microarray datasets分子途径参与前列腺癌形成的见解从公共微阵列数据集.pdfVIP

Molecular Pathways Involved in Prostate Carcinogenesis: Insights from Public Microarray Datasets 1,2 1,3 4,5 1 1 Sarah C. Baetke , Michiel E. Adriaens , Renaud Seigneuric , Chris T. Evelo , Lars M. T. Eijssen * 1 Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands, 2 Department of Experimental Molecular Imaging, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany, 3 Department of Experimental Cardiology, Heart Failure Research Center, Academic Medical Center, ´ University of Amsterdam, Amsterdam, The Netherlands, 4 Universite de Bourgogne, Dijon, France, 5 Heat Shock Proteins and Cancer, INSERM, UMR 866 IFR 100, Faculty of Medicine and Pharmacy, Dijon, France Abstract Background: Prostate cancer is currently the most frequently diagnosed malignancy in men and the second leading cause of cancer-related deaths in industrialized countries. Worldwide, an increase in prostate cancer incidence is expected due to an increased life-expectancy, aging of the population and improved diagnosis. Although the specific underlying mechanisms of prostate carcinogenesis remain unknown, prostate cancer is thought to result from a combination of genetic and environmental factors altering key cellular processes. To elucidate these complex interactions and to contribute to the understanding of prostate cancer progression and metastasis, analysis of large scale gene expression studies using bioinformatics approaches is used to decipher regulation of core processes. Methodology/Principal Findings: In this study, a standardized quality contro