human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo人类乳腺癌细胞株co-express神经上皮,melanocytic分化标记在体外和体内.pdfVIP

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human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo人类乳腺癌细胞株co-express神经上皮,melanocytic分化标记在体外和体内.pdf

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human breast cancer cell lines co-express neuronal, epithelial, and melanocytic differentiation markers in vitro and in vivo人类乳腺癌细胞株co-express神经上皮,melanocytic分化标记在体外和体内

Human Breast Cancer Cell Lines Co-Express Neuronal, Epithelial, and Melanocytic Differentiation Markers In Vitro and In Vivo 1 1 1 3,4 1,2 Qingbei Zhang , Hanli Fan , Jikun Shen , Robert M. Hoffman , H. Rosie Xing * 1 Department of Pathology, Cellular and Radiation Oncology, The University of Chicago, Chicago, Illinois, United States of America, 2 Ludwig Center for Metastasis Research, The University of Chicago, Chicago, Illinois, United States of America, 3 AntiCancer, Inc., San Diego, California, United States of America, 4 Department of Surgery, University of California San Diego, San Diego, California, United States of America Abstract Differentiation programs are aberrant in cancer cells allowing them to express differentiation markers in addition to their tissue of origin. In the present study, we demonstrate the multi-lineage differentiation potential of breast cancer cell lines to express multiple neuronal/glial lineage-specific markers as well as mammary epithelial and melanocytic-specific markers. Multilineage expression was detected in luminal (MCF-7 and SKBR3) and basal (MDA-MB-231) types of human breast cancer cell lines. We also observed comparable co-expression of these three cell lineage markers in MDA-MB-435 cells in vitro, in MDA-MB-435 primary tumors derived from parental and single cell clones and in lung metastases in vivo. Furthermore, ectoderm multi-lineage transdifferentiation was also found in human melanoma (Ul-MeL) and glioblastoma cell lines (U87 and D54). These observations indicate that aberrant multi-lineage transdifferentiation or lineage infidelity may be a wide spread phenomenon in cancer. Citation: Zhang Q, Fan H, Shen J, Hoffman RM, Xin