human cells display reduced apoptotic function relative to chimpanzee cells人类细胞显示了相对于黑猩猩的细胞凋亡作用.pdfVIP

Human Cells Display Reduced Apoptotic Function Relative to Chimpanzee Cells Gaurav Arora., Roman Mezencev., John F. McDonald* School of Biology and Parker H. Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia, United States of America Abstract Previously published gene expression analyses suggested that apoptotic function may be reduced in humans relative to chimpanzees and led to the hypothesis that this difference may contribute to the relatively larger size of the human brain and the increased propensity of humans to develop cancer. In this study, we sought to further test the hypothesis that humans maintain a reduced apoptotic function relative to chimpanzees by conducting a series of apoptotic function assays on human, chimpanzee and macaque primary fibroblastic cells. Human cells consistently displayed significantly reduced apoptotic function relative to the chimpanzee and macaque cells. These results are consistent with earlier findings indicating that apoptotic function is reduced in humans relative to chimpanzees. Citation: Arora G, Mezencev R, McDonald JF (2012) Human Cells Display Reduced Apoptotic Function Relative to Chimpanzee Cells. PLoS ONE 7(9): e46182. doi:10.1371/journal.pone.0046182 Editor: Christopher Mark Norris, University of Kentucky, United States of America Received February 23, 2012; Accepted August 29, 2012; Published September 28, 2012 Copyright: 2012 Arora et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was carried out with the financial support of the Georgia Tech Foundation. The funders had no role in study design, data collection and