molecular poltergeists mitochondrial dna copies (numts) in sequenced nuclear genomes分子恶作剧的线粒体dna的拷贝(numts)核基因组测序.pdfVIP

molecular poltergeists mitochondrial dna copies (numts) in sequenced nuclear genomes分子恶作剧的线粒体dna的拷贝(numts)核基因组测序.pdf

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molecular poltergeists mitochondrial dna copies (numts) in sequenced nuclear genomes分子恶作剧的线粒体dna的拷贝(numts)核基因组测序

Review Molecular Poltergeists: Mitochondrial DNA Copies (numts) in Sequenced Nuclear Genomes Einat Hazkani-Covo1¤*, Raymond M. Zeller1,2, William Martin3 1 National Evolutionary Synthesis Center, Durham, North Carolina, United States of America, 2 Mathematics Undergraduate Program, Duke University, Durham, North ¨ ¨ ¨ ¨ Carolina, United States of America, 3 Institut fur Botanik III, Heinrich-Heine Universitat Dusseldorf, Dusseldorf, Germany The Human Genome—Visible, Ongoing Numt Abstract: The natural transfer of DNA from mitochondria Transfer to the nucleus generates nuclear copies of mitochondrial DNA (numts) and is an ongoing evolutionary process, as Sequenced eukaryotic genomes can be readily scanned for numts genome sequences attest. In humans, five different numts using standard data-mining tools. Attempts to identify numts solely cause genetic disease and a dozen human loci are with computer methods started with partial genome sequences of polymorphic for the presence of numts, underscoring plants and yeast [15,16] followed by scanning of the full genomes of the rapid rate at which mitochondrial sequences reach the human, fruitfly, Plasmodium, and Caenorhabditis [17,18]. Various studies nucleus over evolutionary time. In the laboratory and in focused on the identification of numts specifically in the human nature, numts enter t

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