有哪些信誉好的足球投注网站hypothalamic mtor signaling mediates the orexigenic action of ghrelin下丘脑mtor激素信号介导orexigenic行动.pdfVIP
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hypothalamic mtor signaling mediates the orexigenic action of ghrelin下丘脑mtor激素信号介导orexigenic行动
Hypothalamic mTOR Signaling Mediates the Orexigenic Action of Ghrelin ´ 1,2 ´ 1,2 1,2 ´ ´ 1,2 Luıs Martins , Diana Fernandez-Mallo , Marta G. Novelle , Marıa J. Vazquez , Manuel Tena- 2,3,4 ´ 1,2 ´ 1,2 ´ 1,2 Sempere , Ruben Nogueiras , Miguel Lopez *, Carlos Dieguez * ´ 1 Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases (CIMUS), University of Santiago de Compostela-Instituto de Investigacion ´ ´ Sanitaria (IDIS), Santiago de Compostela, Spain, 2 CIBER Fisiopatologıa de la Obesidad y Nutricion (CIBERobn), Santiago de Compostela, Spain, 3 Department of Cell ´ ´ ´ ´ Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain, 4 Instituto Maimonides de Investigaciones Biomedicas (IMIBIC), Cordoba, Spain Abstract Current evidence suggests that ghrelin, a stomach derived peptide, exerts its orexigenic action through specific modulation of Sirtuin1 (SIRT1)/p53 and AMP-activated protein kinase (AMPK) pathways, which ultimately increase the expression of agouti-related protein (AgRP) and neuropeptide Y (NPY) in the arcuate nucleus of the hypothalamus (A
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