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hiv-1 subtypes and recombinants in northern tanzania distribution of viral quasispecies在坦桑尼亚北部hiv - 1亚型和重组病毒准物种的分布.pdf

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hiv-1 subtypes and recombinants in northern tanzania distribution of viral quasispecies在坦桑尼亚北部hiv - 1亚型和重组病毒准物种的分布

HIV-1 Subtypes and Recombinants in Northern Tanzania: Distribution of Viral Quasispecies 1,2 3 3 3 1,2 1,2 Ireen E. Kiwelu , Vladimir Novitsky , Lauren Margolin , Jeannie Baca , Rachel Manongi , Noel Sam , 1 3 2,4 2 John Shao , Mary F. McLane , Saidi H. Kapiga , M. Essex * 1 Kilimanjaro Christian Medical Centre and College, Tumaini University, Moshi, Tanzania, 2 Kilimanjaro Reproductive Health Program, Moshi, Tanzania, 3 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, United States of America, 4 London School of Hygiene and Tropical Medicine, London, United Kingdom Abstract This study analyzed the distribution and prevalence of HIV-1 subtypes, multiplicity of HIV-1 infection, and frequency of inter- subtype recombination among HIV-1-infected female bar and hotel workers in Moshi, Kilimanjaro Region, Tanzania, from 2004 to 2007. The HIV-1 viral sequences spanning the V1-C5 region of HIV-1 env gp120 were analyzed from 50 subjects by single genome amplification and sequencing (SGA/S) technique. A total of 1740 sequences were amplified and sequenced from the HIV-1 proviral DNA template. The median env sequences analyzed per subject per two time points was 38 (IQR 28– 50) over one year of HIV infection. In a subset of 14 subjects, a total of 239 sequences were obtained from HIV-1 RNA template at the baseline visit. The most prevalent HIV-1 subtypes were A1 (56%) and C (30%), while HIV-1 subtype D and inter-subtype recombinant viruses were found in 6% and 8% of subjects respectively