有哪些信誉好的足球投注网站hypomethylation of a line-1 promoter activates an alternate transcript of the met oncogene in bladders with cancerhypomethylation 1号线启动子的激活另一个记录的致癌基因在膀胱会见了癌症.pdfVIP
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hypomethylation of a line-1 promoter activates an alternate transcript of the met oncogene in bladders with cancerhypomethylation 1号线启动子的激活另一个记录的致癌基因在膀胱会见了癌症
Hypomethylation of a LINE-1 Promoter Activates an Alternate Transcript of the MET Oncogene in Bladders with Cancer 1 2 1,3 1 4 Erika M. Wolff , Hyang-Min Byun , Han F. Han , Shikhar Sharma , Peter W. Nichols , Kimberly D. 5 2 1 1 Siegmund , Allen S. Yang , Peter A. Jones , Gangning Liang * 1 Department of Urology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 2 Department of Hematology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 3 Department of Pharmacology and Pharmaceutical Sciences, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 4 Department of Pathology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America, 5 Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America Abstract It was recently shown that a large portion of the human transcriptome can originate from within repetitive elements, leading to ectopic expression of protein-coding genes. However the mechanism of transcriptional activation of repetitive elements has not been definitively elucidated. For the first time, we directly demonstrate that hypomethylation of retrotransposons can cause altered
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