有哪些信誉好的足球投注网站human u87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2人u87星形细胞瘤细胞入侵引起的互动与整合素βig-h3α5β1涉及calpain-2.pdfVIP
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human u87 astrocytoma cell invasion induced by interaction of βig-h3 with integrin α5β1 involves calpain-2人u87星形细胞瘤细胞入侵引起的互动与整合素βig-h3α5β1涉及calpain-2
Human U87 Astrocytoma Cell Invasion Induced by Interaction of big-h3 with Integrin a5b1 Involves Calpain- 2 1. 2. 1 3 1 1 1 Jie Ma , Wei Cui , Shi-ming He , Yong-hong Duan , Li-jun Heng , Liang Wang , Guo-dong Gao * 1 Department of Neurosurgery, Tangdu Hospital, Forth Military Medical University, Xi’an, China, 2 Department of Endocrinology and Metabolism, Xijing Hospital, Fourth Military Medical University, Xi’an, China, 3 Department of Orthopaedic Surgery, 451 Hospital of Chinese People’s Liberation Army, Xi’an, China Abstract It is known that big-h3 is involved in the invasive process of many types of tumors, but its mechanism in glioma cells has not been fully clarified. Using immunofluorescent double-staining and confocal imaging analysis, and co-immunoprecipitation assays, we found that big-h3 co-localized with integrin a5b1 in U87 cells. We sought to elucidate the function of this interaction by performing cell invasion assays and gelatin zymography experiments. We found that siRNA knockdowns of big-h3 and calpain-2 impaired cell invasion and MMP secretion. Moreover, big-h3, integrins and calpain-2 are known to be regulated by Ca2+, and they are also involved in tumor cell invasion. Therefore, we further investigated if calpain-2 was relevant to big-h3-integrin a5b1 interaction to affect U87 cell invasion. Our data showed that big-h3 co-localized with integrin a5b1 to enhance the invasion of U87 cells, and that calpain-2, is involved in this process, acting as a downstream molecule. Citation: Ma J, Cui W, He S-m, Duan Y-h, Heng L-j, et al. (2012) Human U87 Astrocytoma Cell Invasion Induced by Interaction of big-h3 with Integrin a5b1 Involves Calpain-2. PLoS ONE 7(5): e37
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