有哪些信誉好的足球投注网站high-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma—a systematic review大剂量化疗后自体干细胞移植为转移性rhabdomyosarcoma-a系统性回顾.pdfVIP
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high-dose chemotherapy followed by autologous stem cell transplantation for metastatic rhabdomyosarcoma—a systematic review大剂量化疗后自体干细胞移植为转移性rhabdomyosarcoma-a系统性回顾
High-Dose Chemotherapy Followed by Autologous Stem Cell Transplantation for Metastatic Rhabdomyosarcoma—A Systematic Review 1 ¨ 2 1 1,3 4 Frank Peinemann *, Nicolaus Kroger , Carmen Bartel , Ulrich Grouven , Max Pittler , Rudolf Erttmann5, Michael Kulig1,6 1 Institute for Quality and Efficiency in Health Care (IQWiG), Cologne, Germany, 2 Interdisciplinary Clinic for Stem Cell Transplantation, University Hospital Hamburg- Eppendorf, Hamburg, Germany, 3 Hannover Medical School, Hannover, Germany, 4 German Cochrane Centre, University of Freiburg, Freiburg, Germany, 5 Department of Pediatric Hematology and Oncology, University Hospital Hamburg-Eppendorf, Hamburg, Germany, 6 Federal Joint Committee of the German Health Care System (G-BA), Berlin, Germany Abstract Introduction: Patients with metastatic rhabdomyosarcoma (RMS) have a poor prognosis. The aim of this systematic review is to investigate whether high-dose chemotherapy (HDCT) followed by autologous hematopoietic stem cell transplantation (HSCT) in patients with metastatic RMS has additional benefit or harm compared to standard chemotherapy. Methods: Systematic literature searches were performed in MEDLINE, EMBASE, and The Cochrane Library. All databases were searched from inception to February 2010. PubMed was searched in June 2010 for a last update. In addition to randomized and non-randomized controlled trials, case series and case reports were included to complement results from scant data. The primary outcome was overall survival. A meta-analysis was performed using the hazard ratio as primary effect measure, which was estimated from Cox proportional hazard models or from summary statistics of Kaplan Meier
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