有哪些信誉好的足球投注网站homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of mcp1, hsp60 and adam17homocysteinylated白蛋白促进增加monocyte-endothelial细胞粘附和老年病mcp1 hsp60和adam17.pdfVIP
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homocysteinylated albumin promotes increased monocyte-endothelial cell adhesion and up-regulation of mcp1, hsp60 and adam17homocysteinylated白蛋白促进增加monocyte-endothelial细胞粘附和老年病mcp1 hsp60和adam17
Homocysteinylated Albumin Promotes Increased Monocyte-Endothelial Cell Adhesion and Up-Regulation of MCP1, Hsp60 and ADAM17 1 1 4 1 3 Rosanna Capasso , Irene Sambri , Amelia Cimmino , Sofia Salemme , Cinzia Lombardi , Filomena 3 3 5 2,3 1,2 Acanfora , Ersilia Satta , Donald L. Puppione , Alessandra F. Perna *, Diego Ingrosso 1 Department of Biochemistry and Biophysics ‘‘F. Cedrangolo’’, School of Medicine, Second University of Naples, Naples, Italy, 2 Cardiovascular Research Centre, School of Medicine, Second University of Naples, Naples, Italy, 3 First Division of Nephrology, School of Medicine, Second University of Naples, Naples, Italy, 4 Institute of Genetics and Biophysics, National Research Council, Naples, Italy, 5 The Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America Abstract Rationale: The cardiovascular risk factor homocysteine is mainly bound to proteins in human plasma, and it has been hypothesized that homocysteinylated proteins are important mediators of the toxic effects of hyperhomocysteinemia. It has been recently demonstrated that homocysteinylated proteins are elevated in hemodialysis patients, a high cardiovascular risk population, and that homocysteinylated albumin shows altered properties. Objective: Aim of this work was to investigate the effects of homocysteinylated albumin - the circulating form of this amino acid, utilized at the concentration present in uremia - on monocyte adhesion to a human endothelial cell culture monolayer and the relevant molecular changes induced at both cell levels. Methods
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