有哪些信誉好的足球投注网站hepatocellular carcinoma displays distinct dna methylation signatures with potential as clinical predictors肝细胞癌显示不同的dna甲基化签名与潜在的临床预测因素.pdfVIP
- 1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
hepatocellular carcinoma displays distinct dna methylation signatures with potential as clinical predictors肝细胞癌显示不同的dna甲基化签名与潜在的临床预测因素
Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors 1. 1. 2 ´ 3 Hector Hernandez-Vargas , Marie-Pierre Lambert , Florence Le Calvez-Kelm , Geraldine Gouysse , 2 2 3 1 Sandrine McKay-Chopin , Sean V. Tavtigian , Jean-Yves Scoazec , Zdenko Herceg * 1 Epigenetics Group, International Agency for Research on Cancer (IARC), Lyon, France, 2 Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), Lyon, France, 3 Service d’Anatomie Pathologique, Edouard Herriot Hospital Lyon, Lyon, France Abstract Background: Hepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity. A better understanding of the global deregulation of methylation states and how they correlate with disease progression will aid in the design of strategies for earlier detection and better therapeutic decisions. Methods and Findings: We characterized the changes in promoter methylation in a series of 30 HCC tumors and their respective surrounding tissue and identified methylation signatures associated with major risk factors and clinical correlates. A wide panel of cancer-related gene promoters was analyzed using Illumina bead array technology, and CpG sites were then selected according to their ability to classify clinicopathological parameters. An independent series of HCC tumors and matched surrounding tissue was used for validation of the signatures. We were a
您可能关注的文档
- global change and response of coastal dune plants to the combined effects of increased sand accretion (burial) and nutrient availability全球变化和响应的海岸沙丘植物的联合效应增加砂吸积(葬礼)和营养的可用性.pdf
- gli2 regulates tgf-β1 in human cd4+ t cells implications in cancer and hiv pathogenesisgli2调节tgf-β1 cd4 + t细胞的影响在人类癌症和艾滋病的发病机制.pdf
- global analysis of small molecule binding to related protein targets全球分析小分子结合相关蛋白质的目标.pdf
- global co-existence of two evolutionary lineages of parvovirus b19 1a, different in genome-wide synonymous positions全球共存两种进化谱系的细小病毒b19 1,在全基因组的不同位置.pdf
- global considerations in hierarchical clustering reveal meaningful patterns in data全球考虑分层聚类显示有意义的数据中的模式.pdf
- global analysis of gene expression in the developing brain of gtf2ird1 knockout mice全球的大脑发育的基因表达分析gtf2ird1基因敲除小鼠.pdf
- global data for ecology and epidemiology a novel algorithm for temporal fourier processing modis data全球生态和流行病学数据时间傅里叶处理modis数据的新算法.pdf
- global discriminative learning for higher-accuracy computational gene prediction全球有识别力的学习精度高计算基因预测.pdf
- global demethylation of rat chondrosarcoma cells after treatment with 5-aza-2′-deoxycytidine results in increased tumorigenicity全球脱甲基作用后大鼠软骨肉瘤细胞治疗5-aza-2u2032脱氧胞苷增加致瘤性.pdf
- global cross-talk of genes of the mosquito aedes aegypti in response to dengue virus infection全球相声基因的蚊子埃及伊蚊的应对登革热病毒感染.pdf
- hepatocyte growth factor increases vascular endothelial growth factor-a production in human synovial fibroblasts through c-met receptor pathway肝细胞生长因子增加血管内皮生长因子a生产在人体滑膜成纤维细胞通过c-met受体途径.pdf
- hepatotoxicity or hepatoprotection pattern recognition for the paradoxical effect of the chinese herb rheum palmatum l. in treating rat liver injury肝毒性或hepatoprotection模式识别的矛盾影响中药大黄palmatum l .在治疗大鼠肝损伤.pdf
- hepatitis c vlps delivered to dendritic cells by a tlr2 targeting lipopeptide results in enhanced antibody and cell-mediated responses丙型肝炎种送到树突细胞tlr2瞄准lipopeptide导致增强抗体和细胞介导的反应.pdf
- hepcidin is involved in iron regulation in the ischemic brainhepcidin参与缺血性脑铁监管.pdf
- hepatocyte ikk2 protects mdr2？？ mice from chronic liver failure小鼠肝细胞ikk2保护mdr2 从慢性肝衰竭.pdf
- her1-targeted 86y-panitumumab possesses superior targeting characteristics than 86y-cetuximab for pet imaging of human malignant mesothelioma tumors xenograftsher1-targeted 86 y-panitumumab拥有优越的目标特征比86 y-cetuximab人类恶性间皮瘤的pet成像肿瘤异种移植.pdf
- her2 oncogenic function escapes egfr tyrosine kinase inhibitors via activation of alternative her receptors in breast cancer cellsher2致癌功能逃表皮生长因子受体酪氨酸激酶抑制剂通过激活受体在乳腺癌细胞的替代她.pdf
- hepcidin expression in iron overload diseases is variably modulated by circulating factorshepcidin表达铁过载疾病不定地调制循环因素.pdf
- heptameric targeting ligands against egfr and her2 with high stability and avidityheptameric靶向配体对表皮生长因子受体和her2与高稳定性和活动性.pdf
- hepatocyte growth factor (hgf) inhibits collagen i and iv synthesis in hepatic stellate cells by mirna-29 induction肝细胞生长因子(hgf)抑制胶原蛋白在肝星状细胞和iv合成mirna-29感应.pdf
文档评论（0）