hepatocyte growth factor increases osteopontin expression in human osteoblasts through pi3k, akt, c-src, and ap-1 signaling pathway肝细胞生长因子通过pi3k在人类成骨细胞骨桥蛋白表达增加,akt,c - src,ap-1信号通路.pdfVIP

下载本文档

4
0
约5.19万字
约 11页
2017-09-01 发布于上海
举报
版权申诉

hepatocyte growth factor increases osteopontin expression in human osteoblasts through pi3k, akt, c-src, and ap-1 signaling pathway肝细胞生长因子通过pi3k在人类成骨细胞骨桥蛋白表达增加,akt,c - src,ap-1信号通路.pdf

1、有哪些信誉好的足球投注网站（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

hepatocyte growth factor increases osteopontin expression in human osteoblasts through pi3k, akt, c-src, and ap-1 signaling pathway肝细胞生长因子通过pi3k在人类成骨细胞骨桥蛋白表达增加,akt,c - src,ap-1信号通路

Hepatocyte Growth Factor Increases Osteopontin Expression in Human Osteoblasts through PI3K, Akt, c- Src, and AP-1 Signaling Pathway 1,2,3 3,4,5 6 7,8 Hsien-Te Chen , Hsi-Kai Tsou , Chia-Hao Chang , Chih-Hsin Tang * 1 School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan, 2 Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan, 3 Department of Materials Science and Engineering, Feng Chia University, Taichung, Taiwan, 4 Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan, 5 Center for General Education, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli County, Taiwan, 6 Department of Orthopedic Surgery, Chang-Hwa Hospital, Department of Health Executive Yuan, Chang-Hwa County, Taiwan, 7 Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan, 8 Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan Abstract Background: Hepatocyte growth factor (HGF) has been demonstrated to stimulate osteoblast proliferation and participated bone remodeling. Osteopontin (OPN) is a secreted phosphoglycoprotein that belongs to the SIBLING family and is present during bone mineralization. However, the effects of HGF on OPN expression in human osteoblasts are large unknown. Methodology/Principal Findings: Here we found that HGF induced OPN expression in human osteoblasts dose- dependently. HGF-mediated OPN production was attenuated by c-Met inhibitor and siRNA. Pretreatment of osteoblasts with PI3K inhibitor (Ly294002), Akt inhibitor, c-Src inhibitor (PP2), or AP-1 inhibitor (curcumin) blocked