heat shock protein-derived t-cell epitopes contribute to autoimmune inflammation in pediatric crohns disease热休克protein-derived t细胞抗原表位在小儿克罗恩病导致自身免疫性炎症.pdfVIP

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heat shock protein-derived t-cell epitopes contribute to autoimmune inflammation in pediatric crohns disease热休克protein-derived t细胞抗原表位在小儿克罗恩病导致自身免疫性炎症.pdf

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heat shock protein-derived t-cell epitopes contribute to autoimmune inflammation in pediatric crohns disease热休克protein-derived t细胞抗原表位在小儿克罗恩病导致自身免疫性炎症

Heat Shock Protein-Derived T-Cell Epitopes Contribute to Autoimmune Inflammation in Pediatric Crohn’s Disease 2,3,4¤ 2 2,4 2,4 2,4 Gisella L. Puga Yung , Meredith Fidler , Erika Albani , Naomi Spermon , Gijs Teklenburg , 2 1 1 4 4 Robert Newbury , Nicole Schechter , Theo van den Broek , Berent Prakken , Rosario Billetta , Ranjan Dohil2, Salvatore Albani1,4* 1 Arizona Arthritis Center, University of Arizona, Tucson, Arizona, United States of America, 2 Department of Medicine/Pediatrics, University of California San Diego, La Jolla, California, United States of America, 3 Department of Immunology, Institute of Biomedical Sciences (ICBM), School of Medicine University of Chile, Santiago, Chile, 4 EUREKA Institute for Translational Medicine, Siracusa, Italy Abstract Pediatric Crohn’s disease is a chronic auto inflammatory bowel disorder affecting children under the age of 17 years. A putative etiopathogenesis of Crohn’s disease (CD) is associated with disregulation of immune response to antigens commonly present in the gut microenvironment. Heat shock proteins (HSP) have been identified as ubiquitous antigens with the ability to modulate inflammatory responses associated with several autoimmune diseases. The present study tested the contribution of immune responses to HSP in the amplification of autoimmune inflammation in chronically inflamed mucosa of pediatric CD patients. Colonic biopsies obtained from normal and CD mucosa were stimulated with pairs of Pan HLA-DR bi