heritability of malaria in africa遗传在非洲的疟疾.pdfVIP

Open access, freely available online PLoS MEDICINE Heritability of Malaria in Africa 1,2* 3 3,4 3,4 3,4,5 Margaret J. Mackinnon , Tabitha W. Mwangi , Robert W. Snow , Kevin Marsh , Thomas N. Williams 1 School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2 Department of Pathology, University of Cambridge, Cambridge, United Kingdom, 3 Kenya Medical Research Institute/Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya, 4 Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, United Kingdom, 5 Department of Paediatrics, John Radcliffe Hospital, Oxford, United Kingdom Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. Background Author Contributions: TWM, KM, and TNW conceived and conducted While many individual genes have been identified that confer protection against malaria, the the mild disease cohort study, and overall impact of host genetics on malarial risk remains unknown. pedigree data were collected by MJM and TWM. RWS and TNW designed and conducted the birth Methods and Findings cohort study. Statistical analyses were conducted by MJM. Patients We have used pedigree-based genetic variance component analysis to determine the relative were enrolled by TWM, RWS, and TNW. MJM and TNW wrote the contributions of genetic and other factors to the variability in incidence of malaria and other paper. infectious diseases in two cohorts of children living on the coast of Kenya. In the