herpes simplex virus reorganizes the cellular dna repair and protein quality control machinery单纯疱疹病毒重新组织细胞dna修复和蛋白质质量控制机器.pdfVIP

Pearls Herpes Simplex Virus Reorganizes the Cellular DNA Repair and Protein Quality Control Machinery Sandra K. Weller* Department of Molecular, Microbial and Structural Biology, The University of Connecticut Health Center, Farmington, Connecticut, United States of America When a virus infects a cell, it must contend with a hostile most of the volume of the nucleus, host chromatin is marginalized environment and host machinery that is intrinsically antiviral. One to the periphery of the nucleus [17,18]. Other alterations caused of the hallmarks of herpes simplex virus (HSV) infection is the by HSV infection include modifications in the nucleolus and dramatic reorganization of the infected cell nucleus leading to the disruption of the nuclear lamina [18–20]. formation of large globular replication compartments in which gene expression, DNA replication, and encapsidation occur ([1,2] HSV-1 Hijacks the Host Protein Quality Control and references therein) (see Figure 1). During infection, cellular Machinery factors that are beneficial to the virus are hijacked while other factors and pathways are degraded or inactivated. Two of the Remodeling of the nucleus also involves the reorganization of cellular homeostatic pathways affected by HSV-1 infection are the the cellular PQC machinery, including cellular chaperone proteins protein quality control (PQC) and DNA damage response (Hsp27, Hsp40, Hsc70, Hsp70, and Hsp90) and components of pathways. These events are orchestrated by several viral proteins the 20S proteosome [21,22]. Within the first 2 hours of infection, including the immediate early proteins ICP4, ICP27, ICP0, and Hsc70 and other components of the PQC machinery are recr