health outcome measures in atopic dermatitis a systematic review of trends in disease severity and quality-of-life instruments 1985–2010健康结果措施过敏性皮肤炎疾病严重程度和生活质量的趋势的系统回顾仪器1985 - 2010.pdfVIP

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health outcome measures in atopic dermatitis a systematic review of trends in disease severity and quality-of-life instruments 1985–2010健康结果措施过敏性皮肤炎疾病严重程度和生活质量的趋势的系统回顾仪器1985 - 2010.pdf

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health outcome measures in atopic dermatitis a systematic review of trends in disease severity and quality-of-life instruments 1985–2010健康结果措施过敏性皮肤炎疾病严重程度和生活质量的趋势的系统回顾仪器1985 - 2010

Health Outcome Measures in Atopic Dermatitis: A Systematic Review of Trends in Disease Severity and Quality-of-Life Instruments 1985–2010 Balvinder Rehal, April Armstrong* Department of Dermatology, University of California Davis, Davis, California, United States of America Abstract Background: A number of disease-severity and quality-of-life (QoL) instruments have emerged in atopic dermatitis (AD) in the last decade. Objectives: To identify trends in outcomes instruments used in AD clinical trials and to provide a useful summary of the dimensions and validation studies for the most commonly used measures. Method: All randomized control trials (RCTs) from 1985 to 2010 in the treatment of AD were examined. Results: Among the 791 RCTs reviewed, we identified 20 disease-severity and 14 QoL instruments. Of these outcomes instruments, few have been validated. SCORAD, EASI, IGA and SASSAD were the most commonly used disease-severity instruments and CDLQI, DFI, DLQI and IDQOL were the most frequently used QoL measures. Limitations: The small number of RCTs using QoL scales makes identifying trends for QoL instruments difficult. Conclusion: Overall, there is an increase in the use of disease-severity and QoL instruments in AD clinical trials. Citation: Rehal B, Armstrong A (2011) Health Outcome Measures in Atopic Dermatitis: A Systematic Review of Trends in Disease Severity and Quality-of-Life Instruments 1985–2010. PLoS ONE 6(4): e17520. doi:10.1371/journal.pone.0017520 Editor: Lise Lotte Gluud, Copenhagen University Hospital Gentofte, Denmark Received November 10, 2010; Accepted February 4, 2011; Published April 13, 2011 Copyright: 2011 Rehal, Armstrong. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the