geographic structuring of the plasmodium falciparum sarco(endo)plasmic reticulum ca2+ atpase (pfserca) gene diversity恶性疟原虫的地理构造石棺(endo)血浆的网ca2 + atp酶(pfserca)基因的多样性.pdfVIP
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geographicstructuringoftheplasmodiumfalciparumsarco(endo)plasmicreticulumca2atpase(pfserca)genediversity恶性疟原虫的地理构造石棺(endo)血浆的网ca2atp酶(pfserca)基因的多样性
Geographic Structuring of the Plasmodium falciparum Sarco(endo)plasmic Reticulum Ca2+ ATPase (PfSERCA) Gene Diversity 1,2 . 3. ˜ 3 2 4 1 Ronan Jambou * , Axel Martinelli , Joao Pinto , Simonetta Gribaldo , Eric Legrand , Makhtar Niang , 5 5 ´ 4 2 2 Nimol Kim , Lim Pharath , Beatrice Volnay , Marie Therese Ekala , Christiane Bouchier , Thierry 5 6 6 3 7 7 Fandeur , Pedro Berzosa , Agustin Benito , Isabel Dinis Ferreira , Cynthia Ferreira , Pedro Paulo Vieira , 7 3 3 Maria das Grac¸as Alecrim , Odile Mercereau-Puijalon , Pedro Cravo 1 Institut Pasteur de Dakar, BP 220, Dakar, Senegal, 2 Institut Pasteur, Paris, France, 3 Centro de Malaria e Outras Doenc¸as Tropicais/IHMT/UNL, UEI Biologia Molecular, UEI ´ Malaria, Lisbon, Portugal, 4 Institut Pasteur de Guyane Franc¸aise, Cayenne, French Guiana, 5 Institut Pasteur du Cambodge, Phnom Penh, Cambodia, 6 Centro Nacional de Medicina Tropical, Instituto de Salud Carlos III, Madrid, Spain, 7 Fundacao de Medicina Tropical do Amazonas, Manaus, Brazil Abstract Artemisinin, a thapsigargin-like sesquiterpene has been shown to inhibit the Plasmodium falciparum sarco/endoplasmic reticulum calcium-ATPase PfSERCA. To collect baseline pfserca sequence information before field deployment of Artemisinin-based Combination therapies that may select mutant
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