health-related quality of life in long-term survivors of relapsed childhood acute lymphoblastic leukemia健康相关的生活质量长期复发儿童急性淋巴细胞白血病的幸存者.pdfVIP

Health-Related Quality of Life in Long-Term Survivors of Relapsed Childhood Acute Lymphoblastic Leukemia 1 2 1 1 1 Stefan Essig , Nicolas X. von der Weid , Marie-Pierre F. Strippoli , Cornelia E. Rebholz , Gisela Michel , 1 3 1 Corina S. Rueegg , Felix K. Niggli , Claudia E. Kuehni *, for the Swiss Pediatric Oncology Group (SPOG) 1 Swiss Childhood Cancer Registry, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, 2 Paediatric Hematology-Oncology Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland, 3 Department of Oncology, University Children’s Hospital Zurich, Zurich, Switzerland Abstract Background: Relapses occur in about 20% of children with acute lymphoblastic leukemia (ALL). Approximately one-third of these children can be cured. Their risk for late effects is high because of intensified treatment, but their health-related quality of life (HRQOL) was largely unmeasured. Our aim was to compare HRQOL of ALL survivors with the general population, and of relapsed with non-relapsed ALL survivors. Methodology/Principal Findings: As part of the Swiss Childhood Cancer Survivor Study (SCCSS) we sent a questionnaire to all ALL survivors in Switzerland who had been diagnosed between 1976–2003 at age ,16 years, survived $5 years, and were currently aged $16 years. HRQOL was assessed with the Short Form-36 (SF-36), which measures four aspects of physical health and four aspects of mental health. A score of 50 corresponded to the mean of a healthy reference population. We analyzed data from 457 ALL survivors (response: