genotyping and phylogenetic analysis of yersinia pestis by mlva insights into the worldwide expansion of central asia plague foci鼠疫杆菌的基因分型和系统发育分析mlva见解中亚鼠疫疫源地的全球扩张.pdfVIP

Genotyping and Phylogenetic Analysis of Yersinia pestis by MLVA: Insights into the Worldwide Expansion of Central Asia Plague Foci 1. 1. 2 3 1 1 1 Yanjun Li , Yujun Cui , Yolande Hauck , Mikhail E. Platonov , Erhei Dai , Yajun Song , Zhaobiao Guo , 2 3 3 1 2,4 Christine Pourcel , Svetlana V. Dentovskaya , Andrey P. Anisimov *, Ruifu Yang *, Gilles Vergnaud * ´ 1 Laboratory of Analytical Microbiology, State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Beijing, China, 2 Universite Paris- ´ ´ Sud 11, CNRS, UMR8621, Institut de Genetique et Microbiologie, Orsay, France, 3 State Research Center for Applied Microbiology and Biotechnology, Obolensk, Moscow Region, Russia, 4 DGA/D4S - Mission pour la Recherche et l’Innovation Scientifique, Bagneux, France Abstract Background: The species Yersinia pestis is commonly divided into three classical biovars, Antiqua, Medievalis, and Orientalis, belonging to subspecies pestis pathogenic for human and the (atypical) non-human pathogenic biovar Microtus (alias Pestoides) including several non-pestis subspecies. Recent progress in molecular typing methods enables large-scale investigations in the population structure of this species. It is now possible to test hypotheses about its evolution which were prop