genome-wide association study identified a narrow chromosome 1 region associated with chicken growth traits全基因组关联研究发现一个狭窄的染色体1地区与鸡有关增长特征.pdfVIP

Genome-Wide Association Study Identified a Narrow Chromosome 1 Region Associated with Chicken Growth Traits 1,4. 1,3. 1 1 1 1 2 Liang Xie , Chenglong Luo , Chengguang Zhang , Rong Zhang , Jun Tang , Qinghua Nie , Li Ma , 5 5 2 1 Xiaoxiang Hu , Ning Li , Yang Da *, Xiquan Zhang * 1 Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Guangzhou, Guangdong, China, 2 Department of Animal Science, University of Minnesota, Saint Paul, Minnesota, United States of America, 3 State Key Laboratory of Livestock and Poultry Breeding, Guangzhou, Guangdong, China, 4 Institute of Animal Science Veterinary, Hainan Academy of Agricultural Sciences, Haikou, Hainan, China, 5 College of Biological Science, China Agricultural University, Beijing, China Abstract Chicken growth traits are important economic traits in broilers. A large number of studies are available on finding genetic factors affecting chicken growth. However, most of these studies identified chromosome regions containing putative quantitative trait loci and finding causal mutations is still a challenge. In this genome-wide association study (GWAS), we identified a narrow 1.5 Mb region (173.5–175 Mb) of chicken (Gallus gallus) chromosome (GGA) 1 to be strongly associated with chicken growth using 47,678 SNPs and 489 F2 chickens. The growth traits included aggregate body weight (BW) at 0– 90 d of age measured weekly, biweekly average daily gains (ADG) derived from weekly body weight, and breast muscle weight (BMW), leg muscle weight (LMW) and wing weight (WW) at 90 d of age. Five SNPs in the 1.5 Mb KPNA3-FOXO1A region at GGA1 had the highest sig