gestational weight gain and body mass index in？children results from three german cohort studies妊娠期体重增加和身体质量指数孩子结果从三个德国群组研究.pdfVIP

Gestational Weight Gain and Body Mass Index in Children: Results from Three German Cohort Studies 1 1 2 2 ¨ 3 Andreas Beyerlein , Ina Nehring *, Peter Rzehak , Joachim Heinrich , Manfred J. Muller , Sandra 3 4 5 5 5,6 Plachta-Danielzik , Martin Wabitsch , Melanie Weck , Hermann Brenner , Dietrich Rothenbacher , ¨ 1 Rudiger von Kries 1 Institute of Social Paediatrics and Adolescent Medicine, Ludwig-Maximilians University of Munich, Munich, Germany, 2 Institute of Epidemiology I, Helmholtz Zentrum ¨ Munchen, German Research Center for Environmental Health, Neuherberg, Germany, 3 Institute of Human Nutrition and Food Science, Christian-Albrechts University, Kiel, Germany, 4 University Hospital Ulm, Ulm, Germany, 5 German Cancer Research Center, Heidelberg, Germany, 6 Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany Abstract Introduction: Previous studies suggested potential priming effects of gestational weight gain (GWG) on offspring’s body composition in later life. However, consistency of these effects in normal weight, overweight and obese mothers is less clear. Methods: We combined the individual data of three German cohorts and assessed associations of total and excessive GWG (as defined by criteria of the Institute of Medicine) with offspring’s mean body mass index (BMI) standard deviation scores (SDS) and overweight at the age of 5–6 years (total: n = 6,254). Quantile regression was used to examine potentially different effects on different parts of the BMI SDS distribution. A