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Genetic Polymorphism in a VEGF-Independent Angiogenesis Gene ANGPT1 and Overall Survival of Colorectal Cancer Patients after Surgical Resection 1 2 3 2 4 5 2 Jingyao Dai , Shaogui Wan , Feng Zhou , Ronald E. Myers , Xu Guo , Bingshan Li , Xiaoying Fu , 6 1 2 4 Juan P. Palazzo , Kefeng Dou , Hushan Yang *, Jinliang Xing * 1 Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China, 2 Division of Population Science, Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America, 3 Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi’an, China, 4 State Key Laboratory of Cancer Biology, Cell Engineering Research Center Department of Cell Biology, The Fourth Military Medical University, Xi’an, China, 5 Center for Human Genetics Research, Department of Molecular Physiology Biophysics, Vanderbilt University, Nashville, Tennessee, United States of America, 6 Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America Abstract Background: The VEGF-independent angiogenic signaling plays an important role in the development of colorectal cancer (CRC). However, its implication in the clinical outcome of CRC has not been reported. This study aimed to investigate the association between genetic variations in several major VEGF-independent signaling pathway genes and the overall survival of CRC patients. Methods: Seven single nucleotide polymorphisms (SNPs) in four important VEGF-independent angiogenic genes (ANGPT1, AMOT, DLL4 and ENG) were genotyp