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genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth遗传标记的成年肥胖风险与更早期阶段体重增加和经济增长.pdf

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genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth遗传标记的成年肥胖风险与更早期阶段体重增加和经济增长

Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth 1,2 1,2 1,2 1,2 3 Cathy E. Elks , Ruth J. F. Loos , Stephen J. Sharp , Claudia Langenberg , Susan M. Ring , Nicholas J. 4 5 4 6 1,2 Timpson , Andrew R. Ness , George Davey Smith , David B. Dunger , Nicholas J. Wareham , Ken K. Ong1,2,6* 1 MRC Epidemiology Unit, Addenbrooke’s Hospital, Cambridge, United Kingdom, 2 Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom, 3 Department of Social Medicine, University of Bristol, Bristol, United Kingdom, 4 MRC Centre for Causal Analyses in Translational Epidemiology, Department of Social Medicine, University of Bristol, Bristol, United Kingdom, 5 Department of Oral and Dental Science, University of Bristol, Bristol, United Kingdom, 6 Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom Abstract Background: Genome-wide studies have identified several common genetic variants that are robustly associated with adult obesity risk. Exploration of these genotype associations in children may provide insights into the timing of weight changes leading to adult obesity. Methods and Findings: Children from the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort were genotyped for ten genetic variants previously associated with adult BMI. Eight variants that showed individual associations with childhood BMI (in/near: FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, and ETV5) were used to derive an ‘‘ob