genome-wide association study of body weight in chicken f2 resource population全基因组关联研究鸡的体重f2资源人口.pdfVIP

Genome-Wide Association Study of Body Weight in Chicken F2 Resource Population 1 1 2 1,3 1 2 3 Xiaorong Gu , Chungang Feng , Li Ma , Chi Song , Yanqiang Wang , Yang Da , Huifang Li , Kuanwei 3 4 4 1 1,4 Chen , Shaohui Ye , Changrong Ge , Xiaoxiang Hu *, Ning Li * 1 State Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, People’s Republic of China, 2 Department of Animal Science, University of Minnesota, Saint Paul, Minnesota, United States of America, 3 Institute of Poultry Science, Chinese Academy of Agricultural Sciences, Yangzhou, People’s Republic of China, 4 College of Animal Science and Technology, Yunnan Agricultural University, Kunming, People’s Republic of China Abstract Chicken body weight is an economically important trait and great genetic progress has been accomplished in genetic selective for body weight. To identify genes and chromosome regions associated with body weight, we performed a genome-wide association study using the chicken 60 k SNP panel in a chicken F2 resource population derived from the cross between Silky Fowl and White Plymouth Rock. A total of 26 SNP effects involving 9 different SNP markers reached 5% Bonferroni genome-wide significance. A chicken chromosome 4 (GGA4) region approximately 8.6 Mb in length (71.6– 80.2 Mb) had a large number of significant SNP effects for late growth during weeks 7–12. The LIM domain-binding factor 2 (LDB2) gene in this region had the strongest association with body weight for weeks 7–12 and with average daily gain for weeks 6–12. This GGA4 region was previously reported to