gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population基因基因相互作用导致更高的患2型糖尿病的发展一个德系犹太人.pdfVIP

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gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population基因基因相互作用导致更高的患2型糖尿病的发展一个德系犹太人.pdf

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gene-gene interactions lead to higher risk for development of type 2 diabetes in an ashkenazi jewish population基因基因相互作用导致更高的患2型糖尿病的发展一个德系犹太人

Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population 1,2 3 4 6 7 8 Rosalind J. Neuman *, Jon Wasson , Gil Atzmon , Julio Wainstein , Yair Yerushalmi , Joseph Cohen , 4 5 5 3 Nir Barzilai , Ilana Blech , Benjamin Glaser , M. Alan Permutt 1 Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, 4 Institute of Aging, Department of Medicine and Genetics, Albert Einstein College of Medicine, New York, New York, United States of America, 5 Endocrinology and Metabolism Service, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 6 Diabetes Unit, The E. Wolfson Medical Center, Holon, Israel, 7 Endocrinology Unit, Clalit Health Organization, Tel-Aviv, Israel, 8 Diabetes Clinic, Macabbi Health Service, Tel Aviv, Israel Abstract Background: Evidence has accumulated that multiple genetic and environmental factors play important roles in determining susceptibility to type 2 diabetes (T2D). Although variants from candidate genes have become prime targets for genetic analysis, few studies have considered their interplay. Our goal was to evaluate interactions among SNPs within genes frequently identified as associated with T2D. Methods/Principal Findings: Logistic regression was used to study interacti