genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus全基因组关联识别多个基因组区域与羊的慢病毒的易感性和控制有关.pdfVIP

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genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus全基因组关联识别多个基因组区域与羊的慢病毒的易感性和控制有关.pdf

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genome-wide association identifies multiple genomic regions associated with susceptibility to and control of ovine lentivirus全基因组关联识别多个基因组区域与羊的慢病毒的易感性和控制有关

Genome-Wide Association Identifies Multiple Genomic Regions Associated with Susceptibility to and Control of Ovine Lentivirus 1,2 3 2 1 Stephen N. White *, Michelle R. Mousel , Lynn M. Herrmann-Hoesing , James O. Reynolds , 4 5 3 1,2 Kreg A. Leymaster , Holly L. Neibergs , Gregory S. Lewis , Donald P. Knowles 1 Animal Disease Research Unit, Agricultural Research Service, U. S. Department of Agriculture, Pullman, Washington, United States of America, 2 Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, United States of America, 3 U. S. Sheep Experiment Station, Agricultural Research Service, U. S. Department of Agriculture, Dubois, Indiana, United States of America, 4 Genetics and Breeding Research Unit, U. S. Meat Animal Research Center, Agricultural Research Service, U. S. Department of Agriculture, Clay Center, Nebraska, United States of America, 5 Department of Animal Sciences, Washington State University, Pullman, Washington, United States of America Abstract Background: Like human immunodeficiency virus (HIV), ovine lentivirus (OvLV) is macrophage-tropic and causes lifelong infection. OvLV infects one quarter of U.S. sheep and induces pneumonia and body condition wasting. There is no vaccine to prevent OvLV infection and no cost-effective treatment for infected animals. However, breed differences in prevalence and proviral concentration have indicated a genetic basis for susceptibility to OvLV. A recent study identified TMEM154 variants in OvLV susceptibility. The objective here was to identify additional loci associated