genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias全基因组关联的植入心律转复除颤器激活危及生命的心律失常.pdfVIP

genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias全基因组关联的植入心律转复除颤器激活危及生命的心律失常.pdf

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genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias全基因组关联的植入心律转复除颤器激活危及生命的心律失常

Genome-Wide Association of Implantable Cardioverter- Defibrillator Activation With Life-Threatening Arrhythmias 1 8 1 3 3 3 Sarah S. Murray , Erin N. Smith , Nikki Villarasa , Tara Nahey , Jeff Lande , Harold Goldberg , Marian 9 4 5 6 7 1 Shaw , Lawrence Rosenthal , Brian Ramza , Jamshid Alaeddini , Xinqiang Han , Samir Damani , Orhan 3 2 1 Soykan , Robert C. Kowal *, Eric J. Topol * on behalf of the GAME Investigators 1 Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, California, United States of America, 2 Baylor Heart and Vascular Hospital, Baylor University Medical Center, Dallas, Texas, United States of America, 3 Ventures and New Therapies, Medtronic, Inc, Fridley, Minnesota, United States of America, 4 University of Massachusetts, Worcester, Massachusetts, United States of America, 5 St. Luke’s Health System, Mid America Heart Institute, Kansas City, Missouri, United States of America, 6 Inland Cardiology Associates, Spokane, Washington, United States of America, 7 Richmond Cardiology Associates, Richmond, Indiana, United States of America, 8 Department of Pediatrics and Rady’s Children’s Hospital, University of California at San Diego, School of Medicine, La Jolla, California, United States of America, 9 Sequenom, Inc., San Diego, California, United States of America Abstract Objectives: To identify genetic factors that would be predictive of individuals who require an implantable cardioverter- defibrillator (

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